Examining the Mechanisms of Huachansu Injection on Liver Cancer through Integrated Bioinformatics Analysis

• Published in: Recent patents on anti-cancer drug discovery Vol. 18; no. 3; p. 408
• Main Authors: Huang, Chao-Yuan, Cheng, Yi-Min, Li, Wei, Huang, Yuan-Cheng, Luo, Hu, Zhong, Chong, Liu, Feng-Bin
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2023
• Subjects: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Aldehyde Reductase; Amphibian Venoms - administration & dosage; Aurora Kinase A; Humans; Injections; Liver Neoplasms - drug therapy; Matrix Metalloproteinase 12; Membrane Proteins; Molecular Docking Simulation; Pregnane X Receptor; molecular docking; effector mechanism; network pharmacology; Huachansu injection; hepatocellular carcinoma; weighted gene coexpression network analysis

The objective of this study is to explore the potential anti-liver cancer mechanism of Huachansu injection through integrated bioinformatics analysis. Active ingredients of Huachansu injection (extraction of toad skin) were obtained, and their potential drug targets were predicted via SwissTargetPre...