The Expression of Hormone Receptors as a Gateway toward Understanding Endocrine Actions in Female Pelvic Floor Muscles
To provide an overview of the hormone actions and receptors expressed in the female pelvic floor muscles, relevant for understanding the pelvic floor disorders. We performed a literature review focused on the expression of hormone receptors mainly in the pelvic floor muscles of women and female rats...
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Published in | Endocrine, metabolic & immune disorders drug targets Vol. 20; no. 3; p. 305 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United Arab Emirates
01.01.2020
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Abstract | To provide an overview of the hormone actions and receptors expressed in the female pelvic floor muscles, relevant for understanding the pelvic floor disorders.
We performed a literature review focused on the expression of hormone receptors mainly in the pelvic floor muscles of women and female rats and rabbits.
The impairment of the pelvic floor muscles can lead to the onset of pelvic floor dysfunctions, including stress urinary incontinence in women. Hormone milieu is associated with the structure and function alterations of pelvic floor muscles, a notion supported by the fact that these muscles express different hormone receptors. Nuclear receptors, such as steroid receptors, are up till now the most investigated. The present review accounts for the limited studies conducted to elucidate the expression of hormone receptors in pelvic floor muscles in females.
Hormone receptor expression is the cornerstone in some hormone-based therapies, which require further detailed studies on the distribution of receptors in particular pelvic floor muscles, as well as their association with muscle effectors, involved in the alterations relevant for understanding pelvic floor disorders. |
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AbstractList | To provide an overview of the hormone actions and receptors expressed in the female pelvic floor muscles, relevant for understanding the pelvic floor disorders.
We performed a literature review focused on the expression of hormone receptors mainly in the pelvic floor muscles of women and female rats and rabbits.
The impairment of the pelvic floor muscles can lead to the onset of pelvic floor dysfunctions, including stress urinary incontinence in women. Hormone milieu is associated with the structure and function alterations of pelvic floor muscles, a notion supported by the fact that these muscles express different hormone receptors. Nuclear receptors, such as steroid receptors, are up till now the most investigated. The present review accounts for the limited studies conducted to elucidate the expression of hormone receptors in pelvic floor muscles in females.
Hormone receptor expression is the cornerstone in some hormone-based therapies, which require further detailed studies on the distribution of receptors in particular pelvic floor muscles, as well as their association with muscle effectors, involved in the alterations relevant for understanding pelvic floor disorders. |
Author | Martínez-Gómez, Margarita Castelán, Francisco Cuevas-Romero, Estela |
Author_xml | – sequence: 1 givenname: Francisco surname: Castelán fullname: Castelán, Francisco organization: Tlaxcala Center for Behavioral Biology, Autonomous University of Tlaxcala, Tlaxcala, Mexico – sequence: 2 givenname: Estela surname: Cuevas-Romero fullname: Cuevas-Romero, Estela organization: Tlaxcala Center for Behavioral Biology, Autonomous University of Tlaxcala, Tlaxcala, Mexico – sequence: 3 givenname: Margarita surname: Martínez-Gómez fullname: Martínez-Gómez, Margarita organization: Tlaxcala Center for Behavioral Biology, Autonomous University of Tlaxcala, Tlaxcala, Mexico |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32216732$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Animals Female Gene Expression Gonadal Steroid Hormones - biosynthesis Gonadal Steroid Hormones - genetics Humans Neuroendocrine Cells - metabolism Neuroendocrine Cells - pathology Pelvic Floor - pathology Pelvic Floor - physiology Receptors, Peptide - biosynthesis Receptors, Peptide - genetics Urinary Incontinence, Stress - genetics Urinary Incontinence, Stress - metabolism Urinary Incontinence, Stress - pathology |
Title | The Expression of Hormone Receptors as a Gateway toward Understanding Endocrine Actions in Female Pelvic Floor Muscles |
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