Development of an in Vivo Lipopolysaccharide Inflammation Model to Study the Pharmacodynamics of COX-2 Inhibitors Celecoxib, Mavacoxib, and Meloxicam in Cockatiels (Nymphicus hollandicus)

• Published in: Journal of avian medicine and surgery Vol. 33; no. 4; pp. 349 - 360
• Main Authors: Gasthuys, Elke, Houben, Renée, Haesendonck, Roel, De Baere, Siegrid, Sys, Stanislas U, Morrens, Joachim, Antonissen, Gunther
• Format: Journal Article
• Language: English
• Published: United States Association of Avian Veterinarians 09.12.2019
• Subjects: analgesics; Angiogenesis inhibitors; Animals; Anopheles; anti-inflammatory activity; Anti-inflammatory agents; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; avian; Birds; Body Temperature; Celecoxib; Celecoxib - pharmacology; cockatiel; Cockatoos - physiology; COX-2 inhibitors; Cyclooxygenase 2 Inhibitors - pharmacology; Disease Models, Animal; enzyme inhibition; Female; females; hypothermia; Inflammation; Inflammation - chemically induced; intravenous injection; lipopolysaccharide; lipopolysaccharides; Lipopolysaccharides - administration & dosage; Lipopolysaccharides - adverse effects; Male; males; mavacoxib; medicine; Meloxicam; Meloxicam - pharmacology; Mitogens; Nonsteroidal anti-inflammatory agents; NSAIDS; Nymphicus hollandicus; ORIGINAL STUDIES; Original Study; pain; pharmacodynamic; pharmacodynamics; posture; prostaglandin synthase; prostaglandins; Pyrazoles - pharmacology; Random Allocation; Statistics, Nonparametric; Surgery; Belgium; Nymphicus hollandicus; meloxicam; mavacoxib; celecoxib; NSAIDS; pharmacodynamic; lipopolysaccharide; avian; cockatiel

Nonsteroidal anti-inflammatory drugs (NSAIDs) are used frequently in avian medicine for their antipyretic, analgesic, and anti-inflammatory properties during surgery and for diseases that cause tissue damage and inflammation. NSAIDs inhibit cyclooxygenase (COX) enzymes, which are responsible for the...