Prevalence and risk factors associated with chronic kidney disease in Nepal: evidence from a nationally representative population-based cross-sectional study

• Published in: BMJ open Vol. 12; no. 3; p. e057509
• Main Authors: Poudyal, Anil, Karki, Khem Bahadur, Shrestha, Namuna, Aryal, Krishna Kumar, Mahato, Namra Kumar, Bista, Bihungum, Ghimire, Laxmi, KC, Dirghayu, Gyanwali, Pradip, Jha, Anjani Kumar, Garcia-Larsen, Vanessa, Kuch, Ulrich, Groneberg, David A, Sharma, Sanjib Kumar, Dhimal, Meghnath
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 21.03.2022; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Adult; Biochemistry; Cholesterol; chronic renal failure; Creatinine; Cross-Sectional Studies; Data collection; Diabetes; dialysis; Fasting; Glomerular Filtration Rate; glomerulonephritis; Glucose; High density lipoprotein; Households; Humans; Hypertension; Kidney diseases; Laboratories; Nepal - epidemiology; Phenols; Population; Population-based studies; Prevalence; Public health; Renal Insufficiency, Chronic - epidemiology; Renal Medicine; renal transplantation; Response rates; Risk Factors; Sample size; Sociodemographics; Urine; Nepal; Germany; dialysis; glomerulonephritis; chronic renal failure; renal transplantation
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2021-057509

ObjectiveThis study aimed to determine population-based prevalence of chronic kidney disease (CKD) and its associated factors in Nepal.Study designThe study was a nationwide population-based cross-sectional study.Setting and participantsCross-sectional survey conducted in a nationally representative sample of 12 109 Nepalese adult from 2016 to 2018 on selected chronic non-communicable diseases was examined. Multistage cluster sampling with a mix of probability proportionate to size and systematic random sampling was used for the selection of individuals aged 20 years and above.Primary and secondary outcome measuresPrimary outcome in this study was population-based prevalence of CKD in Nepal. A participant was considered to have CKD if the urine albumin-to-creatinine ratio was greater than or equal to 30 mg/g and/or estimated glomerular filtration rate is less than 60 mL/min/1.73 m2 at baseline and in follow-up using modification of diet in renal disease study equations. The secondary outcome measure was factors associated with CKD in Nepal. The covariate adjusted association of risk factors and CKD was calculated using multivariable binary logistic regression.ResultsThe overall prevalence of CKD in Nepal was 6.0% (95% CI 5.5 to 6.6). Factors independently associated with CKD included older age (adjusted OR (AOR) 2.6, 95% CI 1.9 to 3.6), Dalit caste (AOR 1.6, 95% CI 1.1 to 2.3), hypertension (AOR 2.4, 95% CI 2.0 to 3.0), diabetes mellitus (AOR 3.2, 95% CI 2.5 to 4.1), raised total cholesterol (AOR 1.3, 95% CI 1.0 to 1.6) and increased waist-to-hip ratio (AOR 1.6, 95% CI 1.2 to 2.3).ConclusionThis nationally representative study shows that the prevalence of CKD in the adult population of Nepal is substantial, and it is independently associated with several cardiometabolic traits. These findings warrant longitudinal studies to identify the causes of CKD in Nepal and effective strategies to prevent it.