Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn’s disease - Zuo, Li; Kuo, Wei-Ting; Cao, Feng; Chanez-Paredes, Sandra D; Zeve, Daniel; Mannam, Prabhath; Jean-François, Léa; Day, Anne; Vallen Graham, W; Sweat, Yan Y; Shashikanth, Nitesh; Breault, David T; et al. (Gut, 2023)
Keywords: actin cytoskeleton; Animals; Biopsy; Caco-2 Cells; Cell junctions; Crohn Disease - drug therapy; Crohn Disease - metabolism; Crohn's disease; Epithelial cells; Humans; IBD basic research; Inflammatory bowel disease; Inflammatory bowel diseases; intestinal barrier function; Intestinal Mucosa - metabolism; intestinal stem cell; Intestine; Kinases; Light; Mice; Mice, Knockout; Myosin-light-chain kinase; Myosin-Light-Chain Kinase - metabolism; Organoids; Patients; Permeability; Phosphorylation; Protein interaction; Proteins; Recruitment; Remission (Medicine); Risk factors; Tacrolimus; Tacrolimus - pharmacology; Tacrolimus Binding Proteins - metabolism; Tacrolimus-binding protein; Therapeutic targets; Tight Junctions - physiology; TNF; Tumor necrosis factor; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumors; Womens health; United States--US; Massachusetts; IBD basic research; actin cytoskeleton; intestinal stem cell; intestinal barrier function; TNF