Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma

• Published in: Gut Vol. 68; no. 2; pp. 335 - 346
• Main Authors: Chew, Valerie, Lee, Yun Hua, Pan, Lu, Nasir, Nurul J M, Lim, Chun Jye, Chua, Camillus, Lai, Liyun, Hazirah, Sharifah Nur, Lim, Tony Kiat Hon, Goh, Brian K P, Chung, Alexander, Lo, Richard H G, Ng, David, Filarca, Rene L F, Albani, Salvatore, Chow, Pierce K H
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.02.2019; BMJ Publishing Group
• Series: Original article
• Subjects: Antigen-presenting cells; Antigen-Presenting Cells - immunology; Bioinformatics; Biomarkers, Tumor - immunology; Cancer therapies; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - radiotherapy; CCR5 protein; CD4 antigen; CD56 antigen; CD8 antigen; Cell activation; Cell cycle; Chemokine CCL5 - immunology; Chemokine CXCL16 - immunology; Chemokines; CXCL16 protein; Cytokines; Cytometry; Disease; Disease Progression; Female; Flow Cytometry - methods; Granzyme B; Granzymes - immunology; Hepatocellular carcinoma; Hepatology; Homing receptors; Humans; Immunotherapy; Leukocytes (mononuclear); Leukocytes, Mononuclear - immunology; Liver cancer; Liver Neoplasms - immunology; Liver Neoplasms - radiotherapy; Lymphocytes; Lymphocytes T; Lymphocytes, Tumor-Infiltrating - immunology; Male; Medical prognosis; Metastases; Natural killer cells; Next-generation sequencing; PD-1 protein; Peripheral blood mononuclear cells; Prediction models; Radiation therapy; Singapore; Treatment Outcome; Tumor necrosis factor; Tumor Necrosis Factor-alpha - immunology; Tumors; Yttrium; Yttrium Radioisotopes; Singapore; United States > US; biomarkers; immune activation; Time-of-flight Mass Cytometry (CyTOF); tumor microenvironment; Y90 radioembolization; hepatocellular carcinoma; chemotaxis

ObjectivesYttrium-90 (Y90)-radioembolisation (RE) significantly regresses locally advanced hepatocellular carcinoma and delays disease progression. The current study is designed to deeply interrogate the immunological impact of Y90-RE, which elicits a sustained therapeutic response.DesignTime-of-fli...