Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids

• Published in: Gut Vol. 68; no. 7; pp. 1311 - 1322
• Main Authors: Gao, Yanhang, Zhou, Zhou, Ren, Tianyi, Kim, Seung-Jin, He, Yong, Seo, Wonhyo, Guillot, Adrien, Ding, Yanhua, Wu, Ruihong, Shao, Shuang, Wang, Xiaomei, Zhang, Hong, Wang, Wei, Feng, Dechun, Xu, Mingjiang, Han, Elaine, Zhong, Wei, Zhou, Zhanxiang, Pacher, Pal, Niu, Junqi, Gao, Bin
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.07.2019; BMJ Publishing Group
• Series: Original article
• Subjects: Acetaldehyde; Alcohol use; Alcoholism; Aldehyde dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial - physiology; Animals; Binge Drinking - metabolism; Binge Drinking - pathology; Cell activation; Concanavalin A; Corticosterone; Corticosterone - blood; Cortisol; Cytokines; Dehydrogenases; Disease Models, Animal; Drinking behavior; Enzymes; Epigenetics; Ethanol; Glucocorticoids; Glucose - metabolism; Glycolysis; Health care; Hepatitis; Hepatitis - etiology; Hepatitis - metabolism; Hepatitis - prevention & control; Hepatology; Hormones; Hospitals; Human subjects; Humans; Hydrocortisone - blood; Kinases; Liver; Liver diseases; Lymphocytes; Lymphocytes T; Metabolism; Metabolites; Mice; Splenocytes; T-Lymphocytes - physiology; Tumor necrosis factor-TNF; γ-Interferon; China; AKT; binge drinking; Concanavalin A; glucose metabolism; T-cell hepatitis; glycolysis

ObjectiveAldehyde dehydrogenase 2 (ALDH2), a key enzyme to detoxify acetaldehyde in the liver, exists in both active and inactive forms in humans. Individuals with inactive ALDH2 accumulate acetaldehyde after alcohol consumption. However, how acetaldehyde affects T-cell hepatitis remains unknown.Des...