Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids - Gao, Yanhang; Zhou, Zhou; Ren, Tianyi; Kim, Seung-Jin; He, Yong; Seo, Wonhyo; Guillot, Adrien; Ding, Yanhua; Wu, Ruihong; Shao, Shuang; Wang, Xiaomei; Zhang, Hong; et al. (Gut, 2019)
Keywords: Acetaldehyde; Alcohol use; Alcoholism; Aldehyde dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial - physiology; Animals; Binge Drinking - metabolism; Binge Drinking - pathology; Cell activation; Concanavalin A; Corticosterone; Corticosterone - blood; Cortisol; Cytokines; Dehydrogenases; Disease Models, Animal; Drinking behavior; Enzymes; Epigenetics; Ethanol; Glucocorticoids; Glucose - metabolism; Glycolysis; Health care; Hepatitis; Hepatitis - etiology; Hepatitis - metabolism; Hepatitis - prevention & control; Hepatology; Hormones; Hospitals; Human subjects; Humans; Hydrocortisone - blood; Kinases; Liver; Liver diseases; Lymphocytes; Lymphocytes T; Metabolism; Metabolites; Mice; Splenocytes; T-Lymphocytes - physiology; Tumor necrosis factor-TNF; γ-Interferon; China; AKT; binge drinking; Concanavalin A; glucose metabolism; T-cell hepatitis; glycolysis