Topical 1% 5-fluorouracil in ocular surface squamous neoplasia: a long-term safety study

• Published in: British journal of ophthalmology Vol. 95; no. 3; pp. 355 - 359
• Main Authors: Parrozzani, Raffaele, Lazzarini, Daniela, Alemany-Rubio, Ernesto, Urban, Francesca, Midena, Edoardo
• Format: Journal Article
• Language: English
• Published: BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.03.2011; BMJ Publishing Group; BMJ Publishing Group LTD
• Subjects: Administration, Topical; Adult; Aged; Aged, 80 and over; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Aqueous solutions; Biological and medical sciences; Chemotherapy; conjunctiva; Conjunctival Neoplasms - drug therapy; Conjunctival Neoplasms - pathology; cornea; Disease; drugs; Endothelium; Female; Fluorouracil - administration & dosage; Fluorouracil - adverse effects; Humans; Male; Medical sciences; Microscopy; Microscopy, Confocal; Middle Aged; Miscellaneous; neoplasia; Neoplasm Recurrence, Local - drug therapy; Neoplasms, Squamous Cell - drug therapy; Neoplasms, Squamous Cell - pathology; Ocular surface; Ophthalmology; Patients; Prospective Studies; Skin; Surgery; Treatment Outcome; Tumors; Antineoplastic agent; Ocular; Enzyme; Toxicity; Fluoropyrimidine derivatives; Transferases; Enzyme inhibitor; Malignant tumor; Thymidylate synthase; Long term; Surface; Eye; Local administration; Antimetabolic; Methyltransferases; Pyrimidine derivatives; Ophthalmology; Safety; Cancer; Fluorouracil

Background/aimsThe aim of this study was to evaluate the long-term corneal toxicity of topical chemotherapy with 1% 5-fluorouracil (5-FU) as a sole or adjuvant treatment of ocular surface squamous neoplasia (OSSN).MethodsForty-one consecutive cases of OSSN were included in this prospective study. Pa...