MTOR suppresses autophagy-mediated production of IL25 in allergic airway inflammation

• Published in: Thorax Vol. 75; no. 12; pp. 1047 - 1057
• Main Authors: Li, Wen, Wu, Yinfang, Zhao, Yun, Li, Zhouyang, Chen, Haixia, Dong, Lingling, Liu, Huiwen, Zhang, Min, Wu, Yanping, Zhou, Jiesen, Xiong, Juan, Hu, Yue, Hua, Wen, Zhang, Bin, Qiu, Minzhi, Zhang, Qing-ling, Wei, Chunhua, Wen, Mingchun, Han, Jing, Zhou, Xiaobo, Qiu, Weiliang, Yan, Fugui, Huang, Huaqiong, Ying, Songmin, Choi, Augustine M K, Shen, Huahao, Chen, Zhihua
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Thoracic Society 01.12.2020; BMJ Publishing Group LTD
• Subjects: Adult; Aged; airway epithelium; Airway management; Allergens; allergic lung disease; Animals; Asthma; Asthma - metabolism; Asthma - pathology; Asthma - physiopathology; asthma mechanisms; Autophagy; Autophagy - drug effects; Cells, Cultured; Cytokines; Epithelial Cells - metabolism; Experiments; Female; Gene Knockdown Techniques; Human subjects; Humans; Inflammation; Inflammation - metabolism; Inflammation - pathology; Interleukin-13 - metabolism; Interleukin-13 - pharmacology; Interleukin-17 - biosynthesis; Interleukin-33 - metabolism; Interleukin-33 - pharmacology; Interleukins - metabolism; Kinases; Laboratories; Male; Mice; Microscopy; Microtubule-Associated Proteins - genetics; Middle Aged; Pathogenesis; Proteins; Respiratory Mucosa - physiopathology; Signal Transduction; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Tuberous Sclerosis Complex 2 Protein - metabolism; United States > US; asthma mechanisms; asthma; allergic lung disease; airway epithelium

IntroductionAirway epithelial cells are recognised as an essential controller for the initiation and perpetuation of asthmatic inflammation, yet the detailed mechanisms remain largely unknown. This study aims to investigate the roles and mechanisms of the mechanistic target of rapamycin (MTOR)–autop...