Anti-cancer targeting telomerase inhibitors: β-rubromycin and oleic acid

• Published in: Mini reviews in medicinal chemistry Vol. 12; no. 11; p. 1135
• Main Authors: Mizushina, Yoshiyuki, Takeuchi, Toshifumi, Sugawara, Fumio, Yoshida, Hiromi
• Format: Journal Article
• Language: English
• Published: Netherlands 01.10.2012
• Subjects: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Humans; Models, Molecular; Neoplasms - drug therapy; Neoplasms - enzymology; Oleic Acid - chemistry; Oleic Acid - pharmacology; Quinones - chemistry; Quinones - pharmacology; Telomerase - antagonists & inhibitors; Telomerase - metabolism

Telomerase is a ribonucleoprotein complex that elongates telomeric DNA and appears to play an important part in the cellular immortalization of cancers. In the screening of potent inhibitors of human telomerase, several inhibitors have been discovered from natural and chemical sources. Some compound...