Biological activities of eco-friendly synthesized Hantzsch adducts

• Published in: Medicinal chemistry (Shp-sariqah, United Arab Emirates) Vol. 9; no. 6; p. 889
• Main Authors: Pacheco, Samira R, Braga, Taniris C, da Silva, Daniel L, Horta, Livia P, Reis, Fabiano S, Ruiz, Ana Lucia T G, de Carvalho, Joao E, Modolo, Luzia V, de Fatima, Ângelo
• Format: Journal Article
• Language: English
• Published: Netherlands 01.09.2013
• Subjects: Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Catalysis; Cell Line, Tumor; Cell Proliferation - drug effects; Citric Acid - chemistry; Dihydropyridines - chemical synthesis; Dihydropyridines - chemistry; Dihydropyridines - pharmacology; Free Radical Scavengers - chemical synthesis; Free Radical Scavengers - chemistry; Free Radical Scavengers - pharmacology; Humans; Lactic Acid - chemistry; Molecular Structure; Reactive Nitrogen Species - chemistry; Reactive Oxygen Species - chemistry

Fourteen Hantzsch adducts with different substituents at the C-4 position were synthesized through multicomponent reactions by using citric or lactic acid as catalysts. To the best of our knowledge, this is the first report on the synthesis of such a class of compounds based on multicomponent reacti...