Effect of DHEA and metformin on corpus luteum in mice

• Published in: Reproduction (Cambridge, England) Vol. 138; no. 3; pp. 571 - 579
• Main Authors: Sander, Valeria A, Facorro, Graciela B, Piehl, Lidia, Rubín de Celis, Emilio, Motta, Alicia B
• Format: Journal Article
• Language: English
• Published: England BioScientifica 01.09.2009; BioScientifica Ltd; Society for Reproduction and Fertility
• Subjects: Animals; Corpus Luteum - drug effects; Corpus Luteum - physiology; Dehydroepiandrosterone - pharmacology; Dinoprost - analysis; Dinoprost - metabolism; Female; Hyperandrogenism - pathology; Hyperandrogenism - physiopathology; Hypoglycemic Agents - pharmacology; Lipid Peroxidation - drug effects; Metformin - pharmacology; Mice; Mice, Inbred BALB C; Ovary - drug effects; Ovary - metabolism; Ovary - pathology; Ovary - physiology; Oxidative Stress - drug effects; Oxidative Stress - physiology; Pregnancy; Prostaglandins E - analysis; Prostaglandins E - metabolism

We evaluated the effect of hyperandrogenism in ovaries with functional and regressing corpora lutea (CL) and the action of metformin in preventing these possible alterations using a mouse model. To obtain a CL functional for 9±1 days, immature female mice of the BALB/c strain were injected i.p. with...