Claudin-11 expression and localisation is regulated by androgens in rat Sertoli cells in vitro

• Published in: Reproduction (Cambridge, England) Vol. 133; no. 6; pp. 1169 - 1179
• Main Authors: Kaitu’u-Lino, Tu’uhevaha J, Sluka, Pavel, Foo, Caroline F H, Stanton, Peter G
• Format: Journal Article
• Language: English
• Published: England Society for Reproduction and Fertility 01.06.2007; BioScientifica Ltd
• Subjects: Animals; Blood-Testis Barrier - drug effects; Cells, Cultured; Claudins; Follicle Stimulating Hormone - pharmacology; Immunohistochemistry; Male; Membrane Proteins - analysis; Membrane Proteins - genetics; Membrane Proteins - metabolism; Nerve Tissue Proteins - analysis; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Occludin; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - analysis; Sertoli Cells - chemistry; Sertoli Cells - drug effects; Sertoli Cells - metabolism; Testosterone - pharmacology; Tight Junctions - chemistry; Tight Junctions - drug effects; Tight Junctions - metabolism

Claudin-11 and occludin are protein components in tight junctions (TJs) between Sertoli cells which are important for the maintenance of the blood–testis barrier. Barrier formation occurs during puberty, with evidence suggesting hormonal regulation of both claudin-11 and occludin. This study aimed t...