The expression of ovine placental lactogen, StAR and progesterone-associated steroidogenic enzymes in placentae of overnourished growing adolescent ewes

• Published in: Reproduction (Cambridge, England) Vol. 133; no. 4; pp. 785 - 796
• Main Authors: Lea, Richard G, Wooding, Peter, Stewart, Ian, Hannah, Lisa T, Morton, Stephen, Wallace, Karen, Aitken, Raymond P, Milne, John S, Regnault, Timothy R, Anthony, Russell V, Wallace, Jacqueline M
• Format: Journal Article
• Language: English
• Published: England Society for Reproduction and Fertility 01.04.2007; BioScientifica Ltd
• Subjects: 3-Hydroxysteroid Dehydrogenases - genetics; Aging - physiology; Animal Nutrition Sciences; Animals; Cholesterol Side-Chain Cleavage Enzyme - genetics; Female; Fetal Growth Retardation - metabolism; Gene Expression; Gestational Age; Immunohistochemistry; Maternal Nutritional Physiological Phenomena; Models, Animal; Overnutrition - metabolism; Phosphoproteins - blood; Phosphoproteins - genetics; Placenta - chemistry; Placenta - metabolism; Placental Lactogen - blood; Placental Lactogen - genetics; Pregnancy; Progesterone - blood; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - analysis; Sexual Maturation - physiology; Sheep, Domestic; Steroid 17-alpha-Hydroxylase - genetics; Steroid Hydroxylases - blood; Steroid Hydroxylases - genetics

Overnourishing pregnant adolescent sheep promotes maternal growth but reduces placental mass, lamb birth weight and circulating progesterone. This study aimed to determine whether altered progesterone reflected transcript abundance for StAR (cholesterol transporter) and the steroidogenic enzymes (Cy...