Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products

• Published in: Current topics in medicinal chemistry Vol. 9; no. 16; p. 1494
• Main Authors: Ghosh, Nandita, Sheldrake, Helen M, Searcey, Mark, Pors, Klaus
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.11.2009
• Subjects: Animals; Antibiotics, Antineoplastic - chemistry; Antibiotics, Antineoplastic - pharmacokinetics; Antibiotics, Antineoplastic - therapeutic use; Antineoplastic Agents, Alkylating - chemistry; Antineoplastic Agents, Alkylating - pharmacology; Antineoplastic Agents, Alkylating - therapeutic use; Biological Products - chemistry; Biological Products - pharmacology; Biological Products - therapeutic use; Drug Evaluation, Preclinical; Humans; Indoles - chemistry; Indoles - pharmacology; Indoles - therapeutic use; Pyrrolidinones - chemistry; Pyrrolidinones - pharmacology; Pyrrolidinones - therapeutic use

CC-1065, the duocarmycins and yatakemycin are members of a family of ultrapotent antitumour antibiotics that have been the subject of extensive investigations due to their mode of action and potential in the design of new anticancer therapeutics. The natural products and their analogues exert their...