Asymptomatic subjects with airway obstruction have significant impairment at exercise

• Published in: Thorax Vol. 71; no. 9; pp. 804 - 811
• Main Authors: Soumagne, Thibaud, Laveneziana, Pierantonio, Veil-Picard, Matthieu, Guillien, Alicia, Claudé, Frédéric, Puyraveau, Marc, Annesi-Maesano, Isabella, Roche, Nicolas, Dalphin, Jean-Charles, Degano, Bruno
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group 01.09.2016
• Subjects: Adult; Aged; Bronchial Provocation Tests - methods; Case-Control Studies; Dyspnea - etiology; Dyspnea - physiopathology; Ecology, environment; Exercise Test - methods; Exercise Tolerance - physiology; Female; Forced Expiratory Volume - physiology; Health; Humans; Life Sciences; Male; Mass Screening - methods; Middle Aged; Oxygen Consumption - physiology; Pulmonary Disease, Chronic Obstructive - complications; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - physiopathology; Spirometry - methods; Tidal Volume - physiology; COPD ÀÜ Mechanisms; Exercise; Lung Physiology

BackgroundThe relevance of screening for airway obstruction in subjects not complaining of COPD symptoms may depend on the definition of airway obstruction. Response to exercise in asymptomatic subjects with persistent airway obstruction as defined by a postbronchodilator FEV1/FVC <5th centile lo...