Integrative multiomics enhancer activity profiling identifies therapeutic vulnerabilities in cholangiocarcinoma of different etiologies

• Published in: Gut Vol. 73; no. 6; pp. 966 - 984
• Main Authors: Hong, Jing Han, Yong, Chern Han, Heng, Hong Lee, Chan, Jason Yongsheng, Lau, Mai Chan, Chen, Jianfeng, Lee, Jing Yi, Lim, Abner Herbert, Li, Zhimei, Guan, Peiyong, Chu, Pek Lim, Boot, Arnoud, Ng, Sheng Rong, Yao, Xiaosai, Wee, Felicia Yu Ting, Lim, Jeffrey Chun Tatt, Liu, Wei, Wang, Peili, Xiao, Rong, Zeng, Xian, Sun, Yichen, Koh, Joanna, Kwek, Xiu Yi, Ng, Cedric Chuan Young, Klanrit, Poramate, Zhang, Yaojun, Lai, Jiaming, Tai, David Wai Meng, Pairojkul, Chawalit, Dima, Simona, Popescu, Irinel, Hsieh, Sen-Yung, Yu, Ming-Chin, Yeong, Joe, Kongpetch, Sarinya, Jusakul, Apinya, Loilome, Watcharin, Tan, Patrick, Tan, Jing, Teh, Bin Tean
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.06.2024; BMJ Publishing Group LTD
• Subjects: Animals; Aristolochic acid; Bile Duct Neoplasms - drug therapy; Bile Duct Neoplasms - genetics; Bile Duct Neoplasms - metabolism; Bile Duct Neoplasms - pathology; CANCER; Cancer therapies; Carcinogenesis; Cell Line, Tumor; Chemotherapy; CHOLANGIOCARCINOMA; Cholangiocarcinoma - drug therapy; Cholangiocarcinoma - genetics; Cholangiocarcinoma - metabolism; Cholangiocarcinoma - pathology; DNA methylation; Epigenetics; Estrogens; Etiology; Gene expression; Gene Expression Profiling - methods; Hepatology; Humans; Immunogenicity; Immunohistochemistry; Infections; Liver; Malignancy; Mice; MOLECULAR ONCOLOGY; Multiomics; Mutation; Oxidative phosphorylation; Phosphorylation; Population studies; Signal transduction; Therapeutic targets; TOR protein; Transcriptomics; Tumorigenesis; Tumors; CHOLANGIOCARCINOMA; CANCER; MOLECULAR ONCOLOGY

ObjectivesCholangiocarcinoma (CCA) is a heterogeneous malignancy with high mortality and dismal prognosis, and an urgent clinical need for new therapies. Knowledge of the CCA epigenome is largely limited to aberrant DNA methylation. Dysregulation of enhancer activities has been identified to affect...