Liver injury is independently associated with adverse clinical outcomes in patients with COVID-19

• Published in: Gut Vol. 70; no. 4; pp. 733 - 742
• Main Authors: Yip, Terry Cheuk-Fung, Lui, Grace Chung-Yan, Wong, Vincent Wai-Sun, Chow, Viola Chi-Ying, Ho, Tracy Hang-Yee, Li, Timothy Chun-Man, Tse, Yee-Kit, Hui, David Shu-Cheong, Chan, Henry Lik-Yuen, Wong, Grace Lai-Hung
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.04.2021; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Adrenal Cortex Hormones - administration & dosage; Adrenal Cortex Hormones - adverse effects; Adult; Age; Alanine; Alanine transaminase; Alanine Transaminase - blood; Antibiotics; Antiretroviral drugs; Antiviral Agents - administration & dosage; Antiviral Agents - adverse effects; Aspartate aminotransferase; Aspartate Aminotransferases - blood; Bile; cholestasis; Clinical outcomes; Codes; Coronaviridae; Coronaviruses; Corticosteroids; COVID-19; COVID-19 - blood; COVID-19 - complications; COVID-19 - diagnosis; COVID-19 - drug therapy; Diabetes; Diabetes mellitus; Disease; Drug Combinations; Female; Gallbladder diseases; Hepatitis; Hepatology; Hong Kong - epidemiology; Hospitalization - statistics & numerical data; Hospitals; Humans; Hypertension; Infections; Interferon; Laboratories; Liver; Liver - drug effects; Liver - virology; liver function test; Liver Function Tests - methods; Liver Function Tests - statistics & numerical data; Lopinavir; Lopinavir - administration & dosage; Lopinavir - adverse effects; Male; Mechanical ventilation; Middle East respiratory syndrome; Respiratory diseases; Retrospective Studies; Ribavirin; Ribavirin - administration & dosage; Ribavirin - adverse effects; Ritonavir; Ritonavir - administration & dosage; Ritonavir - adverse effects; SARS-CoV-2 - isolation & purification; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Ventilators; Hong Kong; Hong Kong China; China; hepatitis; cholestasis; liver function test

ObjectiveData on serial liver biochemistries of patients infected by different human coronaviruses (HCoVs) are lacking. The impact of liver injury on adverse clinical outcomes in coronavirus disease 2019 (COVID-19) patients remains unclear.DesignThis was a retrospective cohort study using data from...