Effect of Helicobacter pylori on gastrointestinal microbiota: a population-based study in Linqu, a high-risk area of gastric cancer

• Published in: Gut Vol. 69; no. 9; pp. 1598 - 1607
• Main Authors: Guo, Yang, Zhang, Yang, Gerhard, Markus, Gao, Juan-Juan, Mejias-Luque, Raquel, Zhang, Lian, Vieth, Michael, Ma, Jun-Ling, Bajbouj, Monther, Suchanek, Stepan, Liu, Wei-Dong, Ulm, Kurt, Quante, Michael, Li, Zhe-Xuan, Zhou, Tong, Schmid, Roland, Classen, Meinhard, Li, Wen-Qing, You, Wei-Cheng, Pan, Kai-Feng
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.09.2020; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Age; Anti-Bacterial Agents - therapeutic use; Antibiotics; Bacteria; bacterial interactions; Biopsy; Biopsy - methods; Carcinogenesis; Deoxyribonucleic acid; DNA; Drug resistance; Dysbacteriosis; Dysbiosis - diagnosis; Dysbiosis - microbiology; Dysplasia; Endoscopy; Epidemiology; Feces - microbiology; Female; Gastric cancer; gastric diseases; Gastric Mucosa - microbiology; Gastric Mucosa - pathology; gastric pre-cancer; Gastritis; Gastritis, Atrophic - microbiology; Gastritis, Atrophic - pathology; Gastrointestinal Microbiome - genetics; Gut Microbiota; Helicobacter Infections - drug therapy; Helicobacter Infections - pathology; Helicobacter pylori; Helicobacter pylori - isolation & purification; Helicobacter pylori - pathogenicity; helicobacter pylori - treatment; Humans; Intestinal microflora; Intestine; Laboratories; Male; Metabolism; Metaplasia; Metaplasia - microbiology; Metaplasia - pathology; Microbial Interactions; Microbiota; Middle Aged; Mucosa; Population studies; Population-based studies; Prevention; RNA, Ribosomal, 16S - isolation & purification; rRNA 16S; Stomach Neoplasms - microbiology; Stomach Neoplasms - pathology; Studies; Taxonomy; Beijing China; China; bacterial interactions; gastric diseases; gastric pre-cancer; helicobacter pylori - treatment

ObjectiveGastrointestinal microbiota may be involved in Helicobacter pylori-associated gastric cancer development. The aim of this study was to explore the possible microbial mechanisms in gastric carcinogenesis and potential dysbiosis arising from H. pylori infection.DesignDeep sequencing of the mi...