Effect of insulin resistance on whole blood mRNA and microRNA expression affecting bone turnover

• Published in: European journal of endocrinology Vol. 181; no. 5; pp. 525 - 537
• Main Authors: Razny, Urszula, Polus, Anna, Goralska, Joanna, Zdzienicka, Anna, Gruca, Anna, Kapusta, Maria, Biela, Maria, Dembinska-Kiec, Aldona, Solnica, Bogdan, Malczewska-Malec, Malgorzata
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.11.2019; Oxford University Press
• Subjects: Adult; Antagonists; Blood; Bone Remodeling - physiology; Bone turnover; Clinical Study; Cross-Sectional Studies; Dkk1 protein; DNA microarrays; Enzyme-Linked Immunosorbent Assay; Female; Frizzled-related protein 1; Gene expression; Glucose; Glucose Tolerance Test; Homeostasis; Humans; Insulin; Insulin resistance; Insulin Resistance - physiology; Male; Microarray Analysis; MicroRNAs; MicroRNAs - blood; Middle Aged; miRNA; Obesity; Obesity - etiology; Obesity - metabolism; Osteoblastogenesis; Osteoblasts; Osteoblasts - metabolism; Osteocalcin; Osteoclasts - metabolism; RNA, Messenger - blood; SOST protein; Wnt protein; Wnt Signaling Pathway - physiology

Objective To evaluate the effect of insulin resistance in obesity on the expression in whole blood of mRNA and miRNA affecting bone homeostasis as well as to estimate the influence of oral glucose load (OGTT) on serum osteocalcin concentration in obese individuals with and without insulin resistance...