Telomere length is independently associated with all-cause mortality in chronic heart failure

• Published in: Heart (British Cardiac Society) Vol. 108; no. 2; pp. 124 - 129
• Main Authors: Romaine, Simon P R, Denniff, Matthew, Codd, Veryan, Nath, Mintu, Koekemoer, Andrea, Anker, Stefan D, Cleland, John G, Filippatos, Gerasimos, Levin, Daniel, Metra, Marco, Mordi, Ify R, Ouwerkerk, Wouter, ter Maaten, Jozine M, van Veldhuisen, Dirk J, Zannad, Faiez, Ng, Leong L, van der Harst, Pim, Lang, Chim C, Voors, Adriaan A, Nelson, Christopher P, Samani, Nilesh J
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Cardiovascular Society 01.01.2022; BMJ Publishing Group LTD
• Subjects: Age; Beta blockers; biomarkers; Body mass index; Cell division; Chronic Disease; Cohort Studies; Diuretics; Ejection fraction; genetics; Heart failure; Heart Failure - diagnosis; Heart Failure - genetics; Heart failure and cardiomyopathies; Hospitalization; Humans; Ischemia; Laboratories; Leukocytes; Medical prognosis; Mortality; Patients; Peptides; Regression analysis; Risk Factors; Telomerase; Telomere - genetics; Variables; heart failure; biomarkers; genetics

ObjectivePatients with heart failure have shorter mean leucocyte telomere length (LTL), a marker of biological age, compared with healthy subjects, but it is unclear whether this is of prognostic significance. We therefore sought to determine whether LTL is associated with outcomes in patients with...