Variability in biological monitoring of organic solvent exposure. II. Application of a population physiological model

• Published in: British Journal of Industrial Medicine Vol. 46; no. 8; pp. 547 - 558
• Main Authors: Droz, P O, Wu, M M, Cumberland, W G
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.08.1989; British Medical Association; BMJ; BMJ Publishing Group LTD
• Subjects: Benzene - analysis; Biological and medical sciences; Blood; Body Constitution; Chemical and industrial products toxicology. Toxic occupational diseases; Environmental assessment; Environmental Exposure; Environmental Monitoring; Ethane - analogs & derivatives; Ethane - analysis; Humans; Hydrocarbons, Chlorinated - analysis; Kidney - physiology; Liver - physiology; Medical sciences; Metabolism; Metabolites; Models, Biological; Renal function; Solvents; Somatotypes; Styrene; Styrenes; Styrenes - analysis; Toluene - analysis; Toxicology; Trichloroethanes - blood; Trichloroethylene - urine; Urine; Workloads; Human; Organic solvent; Investigation method; Interindividual comparison; Biological marker; Compartment model; Simulation model; Occupational exposure; Statistical study; Biological monitoring

A physiological population model is used to study the variability associated with the biological monitoring of solvent exposure. The model consists of a combination of a physiological compartmental model and statistical simulation technique. Variable components considered are: exposure concentration...