Designer Natriuretic Peptides

• Published in: Journal of investigative medicine Vol. 57; no. 1; pp. 18 - 21
• Main Authors: Lee, Candace Y. W., Lieu, Hsiao, Burnett, John C.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2009; Sage Publications Ltd
• Subjects: Blood pressure; Design; Drug Design; Humans; Metabolic disorders; Natriuretic Peptides; Studies; Veins & arteries; hybrid peptides; renal function; natriuretic peptide

Designer natriuretic peptides (NPs) are novel hybrid peptides that are engineered from the native NPs through addition, deletion, or substitution of amino acid(s) with a goal toward optimization of pharmacological actions while minimizing undesirable effects. In this article, selected peptides that...