Uterine decidual niche modulates the progressive dedifferentiation of spiral artery vascular smooth muscle cells during human pregnancy

• Published in: Biology of reproduction Vol. 104; no. 3; pp. 624 - 637
• Main Authors: Ma, Yeling, Yu, Xin, Zhang, Lanmei, Liu, Juan, Shao, Xuan, Li, Yu-Xia, Wang, Yan-Ling
• Format: Journal Article
• Language: English
• Published: United States Society for the Study of Reproduction 01.03.2021; Oxford University Press
• Subjects: Analysis; Antibodies; Apoptosis; Biology; Cell Differentiation; Cell Proliferation; decidual immune cells; decidual stromal cells; dedifferentiation; extravillous trophoblast; Female; Fetuses; Humans; Killer cells; Killer Cells, Natural - physiology; Laboratories; Macrophages - physiology; Morphology; Muscle proteins; Muscle, Smooth, Vascular - cytology; Myocytes, Smooth Muscle - physiology; Myosin; Pregnancy; Pregnant women; RESEARCH ARTICLE; Smooth muscle; Stem cells; uterine spiral artery; Uterus - blood supply; Vascular Remodeling - physiology; vascular smooth muscle cells; Veins & arteries; China; uterine spiral artery; dedifferentiation; extravillous trophoblast; decidual immune cells; decidual stromal cells; vascular smooth muscle cells

Uterine spiral artery (SPA) remodeling is a crucial event during pregnancy to provide enough blood supply to maternal–fetal interface and meet the demands of the growing fetus. Along this process, the dynamic change and the fate of spiral artery vascular smooth muscle cells (SPA–VSMCs) have long bee...