Use of multicomponent, domino, and other one-pot syntheses on solid phase: powerful tools for the generation of libraries of diverse and complex compounds

• Published in: Combinatorial chemistry & high throughput screening Vol. 6; no. 7; p. 693
• Main Authors: Pulici, M, Cervi, G, Martina, K, Quartieri, F
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.11.2003
• Subjects: Chemistry, Organic - methods; Combinatorial Chemistry Techniques; Drug Design; Organic Chemicals - chemical synthesis; Organic Chemicals - pharmacology

The availability of small organic molecules covering as much chemical space as possible is seen as the only means that guarantees potential modulation of the many biological targets that are ultimately being unveiled by genomics. Therefore diversity oriented organic synthesis is rapidly becoming one...