HOXA10 improves endometrial receptivity by upregulating E-cadherin

• Published in: Biology of reproduction Vol. 106; no. 5; pp. 992 - 999
• Main Authors: Bi, Yin, Huang, Weiyu, Yuan, Lifang, Chen, Saiqiong, Liao, Shengbin, Fu, Xiaoqian, Liu, Bo, Yang, Yihua
• Format: Journal Article
• Language: English
• Published: United States Society for the Study of Reproduction 17.05.2022; Oxford University Press
• Subjects: Animals; Antigens, CD - genetics; Biomarkers; Cadherins - genetics; Cell Line, Tumor; Chromatin; Conserved sequence; E-cadherin; Education; embryo implantation; Embryo Implantation - physiology; endometrial receptivity; Endometrium; Endometrium - metabolism; Epithelium; Female; Gene expression; Homeobox; Homeobox A10 Proteins - genetics; HOXA10; Humans; Immunoprecipitation; Infertility; Laboratories; Medical research; Menstruation; Mice; Polymerase chain reaction; Proteins; recurrent implantation failure; RESEARCH ARTICLE; RNA, Small Interfering - genetics; siRNA; Spheroids; HOXA10; recurrent implantation failure; endometrial receptivity; E-cadherin; embryo implantation

In the endometrium of women with recurrent implantation failure and unexplained recurrent miscarriage, the expression levels of homeobox A10 and E-cadherin were positively correlated. To explore whether homeobox A10 regulates E-cadherin during endometrial receptivity establishment, Ishikawa and RL95...