Matrix metalloproteinases as drug targets in preeclampsia

• Published in: Current drug targets Vol. 14; no. 3; p. 325
• Main Authors: Palei, Ana C T, Granger, Joey P, Tanus-Santos, Jose E
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.03.2013
• Subjects: Female; Humans; Matrix Metalloproteinase Inhibitors - therapeutic use; Matrix Metalloproteinases - physiology; Pre-Eclampsia - drug therapy; Pre-Eclampsia - enzymology; Pre-Eclampsia - etiology; Pregnancy - physiology
• ISSN: 1873-5592
• DOI: 10.2174/1389450111314030004

Preeclampsia is an important syndrome complicating pregnancy. While the pathogenesis of preeclampsia is not entirely known, poor placental perfusion leading to widespread maternal endothelial dysfunction is accepted as a major mechanism. It has been suggested that altered placental expression of mat...