Comparative oral monotherapy of psilocybin, lysergic acid diethylamide, 3,4-methylenedioxymethamphetamine, ayahuasca, and escitalopram for depressive symptoms: systematic review and Bayesian network meta-analysis

• Published in: BMJ (Online) Vol. 386; p. e078607
• Main Authors: Hsu, Tien-Wei, Tsai, Chia-Kuang, Kao, Yu-Chen, Thompson, Trevor, Carvalho, Andre F, Yang, Fu-Chi, Tseng, Ping-Tao, Hsu, Chih-Wei, Yu, Chia-Ling, Tu, Yu-Kang, Liang, Chih-Sung
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 21.08.2024; BMJ Publishing Group LTD; BMJ Publishing Group Ltd
• Subjects: Administration, Oral; Adverse events; Antidepressants; Banisteriopsis; Bayes Theorem; Bayesian analysis; Citalopram; Clinical trials; Congenital defects; Depression - drug therapy; Drug dosages; Ecstasy; Escitalopram - administration & dosage; Escitalopram - therapeutic use; Hallucinogens - administration & dosage; Hallucinogens - adverse effects; Hallucinogens - therapeutic use; Humans; LSD; Lysergic acid diethylamide; Lysergic Acid Diethylamide - administration & dosage; Lysergic Acid Diethylamide - adverse effects; Lysergic Acid Diethylamide - therapeutic use; Lysergide; MDMA; Mental depression; Meta-analysis; N-Methyl-3,4-methylenedioxyamphetamine - administration & dosage; N-Methyl-3,4-methylenedioxyamphetamine - adverse effects; N-Methyl-3,4-methylenedioxyamphetamine - therapeutic use; Patients; Placebos; Psilocybin; Psilocybin - administration & dosage; Psilocybin - adverse effects; Psilocybin - therapeutic use; Psychedelic drugs; Randomized Controlled Trials as Topic; Suicide; Treatment Outcome

AbstractObjectiveTo evaluate the comparative effectiveness and acceptability of oral monotherapy using psychedelics and escitalopram in patients with depressive symptoms, considering the potential for overestimated effectiveness due to unsuccessful blinding.DesignSystematic review and Bayesian netwo...