Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: a systematic review and meta-analysis

• Published in: Archives of disease in childhood. Fetal and neonatal edition Vol. 101; no. 2; pp. F127 - F136
• Main Authors: Terrin, Gianluca, Conte, Francesca, Oncel, Mehmet Yekta, Scipione, Antonella, McNamara, Patrick J, Simons, Sinno, Sinha, Rahul, Erdeve, Omer, Tekgunduz, Kadir S, Dogan, Mustafa, Kessel, Irena, Hammerman, Cathy, Nadir, E, Yurttutan, Sadik, Jasani, Bonny, Alan, Serdar, Manguso, Francesco, De Curtis, Mario
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.03.2016
• Subjects: Acetaminophen - therapeutic use; Age; Analgesics; Cyclooxygenase Inhibitors - therapeutic use; Drug dosages; Ductus Arteriosus, Patent - drug therapy; Humans; Ibuprofen - therapeutic use; Infant, Newborn; Infant, Premature; Meta-analysis; Morbidity; Mortality; Neonates; Premature birth; Researchers; Safety; Studies; Neonatology; Cardiology; Intensive Care; Therapeutics

ObjectivesWe performed a systematic review and meta-analysis of all the available evidence to assess the efficacy and safety of paracetamol for the treatment of patent ductus arteriosus (PDA) in neonates, and to explore the effects of clinical variables on the risk of closure.Data sourceMEDLINE, Sco...