Systematic review of randomised clinical trials on topical ciclosporin A for the treatment of dry eye disease

• Published in: British journal of ophthalmology Vol. 98; no. 8; pp. 1016 - 1022
• Main Authors: Sacchetti, Marta, Mantelli, Flavio, Lambiase, Alessandro, Mastropasqua, Alessandra, Merlo, Daniela, Bonini, Stefano
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.08.2014
• Subjects: Administration, Topical; Chronic illnesses; Clinical trials; Cyclosporine - administration & dosage; Cyclosporine - adverse effects; Dry Eye Syndromes - drug therapy; Eye diseases; Humans; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - adverse effects; Medical Subject Headings-MeSH; Ophthalmic Solutions - administration & dosage; Ophthalmic Solutions - adverse effects; Quality; Randomized Controlled Trials as Topic; Research Design; Studies; Cornea; Immunology; Clinical Trial; Conjunctiva; Ocular surface

Aims Topical ciclosporin A (CsA) is a therapeutic option for dry eye disease (DED) to control ocular surface inflammation and improve tear function. The aim of this study is to systematically review data from randomised clinical trials (RCTs) evaluating efficacy and safety of topical CsA treatment f...