HLA-B27 and ankylosing spondylitis geographic distribution versus malaria endemic: casual or causal liaison?
[...]support to this hypothesis comes from western India, an area of low and seasonal transmission of Plasmodium falciparum, which is more likely to infect HLA-B27 positive individuals. 5 The selective pressure by malaria in some geographical areas has left behind gene variants that may eventually c...
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Published in | Annals of the rheumatic diseases Vol. 67; no. 1; pp. 138 - 140 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
London
BMJ Publishing Group Ltd and European League Against Rheumatism
01.01.2008
BMJ BMJ Publishing Group LTD |
Subjects | |
Online Access | Get full text |
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Summary: | [...]support to this hypothesis comes from western India, an area of low and seasonal transmission of Plasmodium falciparum, which is more likely to infect HLA-B27 positive individuals. 5 The selective pressure by malaria in some geographical areas has left behind gene variants that may eventually contribute to the spread of new infectious diseases or to susceptibility to common diseases. 6 This may be the case for some HLA-B alleles such as B*53 or B*35, conferring resistance to malaria and susceptibility to AIDS, respectively. |
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Bibliography: | local:annrheumdis;67/1/138 istex:9AA9ADE8BE1E3F3EC610649F83C231A9555381AE ark:/67375/NVC-6C2JS5GW-G href:annrheumdis-67-138.pdf ArticleID:ar72488 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 SourceType-Other Sources-1 content type line 63 ObjectType-Correspondence-1 |
ISSN: | 0003-4967 1468-2060 |
DOI: | 10.1136/ard.2007.072488 |