Human Umbilical Cord Mesenchymal Stem Cells Promote Macrophage PD-L1 Expression and Attenuate Acute Lung Injury in Mice

• Published in: Current stem cell research & therapy
• Main Authors: Tu, Chengshu, Wang, Zhangfan, Xiang, E, Zhang, Quan, Zhang, Yaqi, Wu, Ping, Li, Changyong, Wu, Dongcheng
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2022
• Subjects: pulmonary inflammation; prostaglandin E2; acute lung injury; human umbilical cord mesenchymal stem cells; programmed cell death protein ligand 1

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) remains a serious clinical problem but has no approved pharmacotherapy. Mesenchymal stem cells (MSCs) represent an attractive therapeutic tool for tissue damage and inflammation owing to their unique immunomodulatory properties. The...