Synthesis and biological activity of 3-(2, 8, 9-trioxa-aza-1-germatricyclo [3. 3. 3. 0]undecane-1-yl)-hydroxycinnamic acids

The new germanium compounds of cinnamic acid, RC(6)H(4)CHGe(OCH(2)CH(2))(3)NCH(2)COOH R=H (I), 2-OH (II), 3-OH (III), 4-OH (IV), have been obtained to study anti-tumor activities. Compounds (I-IV) were prepared by the electrophilic addition reaction and nucleophilic substitution reaction. Biological...

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Published inMedicinal chemistry (Shp-sariqah, United Arab Emirates) Vol. 3; no. 5; p. 466
Main Authors Ye, Lianbao, Zhang, Wanjin
Format Journal Article
LanguageEnglish
Published Netherlands 01.09.2007
Subjects
Coumaric Acids - chemical synthesis
Coumaric Acids - pharmacology
Gas Chromatography-Mass Spectrometry
Magnetic Resonance Spectroscopy
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Abstract The new germanium compounds of cinnamic acid, RC(6)H(4)CHGe(OCH(2)CH(2))(3)NCH(2)COOH R=H (I), 2-OH (II), 3-OH (III), 4-OH (IV), have been obtained to study anti-tumor activities. Compounds (I-IV) were prepared by the electrophilic addition reaction and nucleophilic substitution reaction. Biological investigation has demonstrated that all compounds (I-IV) are lower toxicity with strongly anti-tumor activity than positive control.
AbstractList The new germanium compounds of cinnamic acid, RC(6)H(4)CHGe(OCH(2)CH(2))(3)NCH(2)COOH R=H (I), 2-OH (II), 3-OH (III), 4-OH (IV), have been obtained to study anti-tumor activities. Compounds (I-IV) were prepared by the electrophilic addition reaction and nucleophilic substitution reaction. Biological investigation has demonstrated that all compounds (I-IV) are lower toxicity with strongly anti-tumor activity than positive control.
Author Zhang, Wanjin
Ye, Lianbao
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/17897072$$D View this record in MEDLINE/PubMed
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Snippet The new germanium compounds of cinnamic acid, RC(6)H(4)CHGe(OCH(2)CH(2))(3)NCH(2)COOH R=H (I), 2-OH (II), 3-OH (III), 4-OH (IV), have been obtained to study...
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StartPage 466
SubjectTerms Coumaric Acids - chemical synthesis
Coumaric Acids - pharmacology
Gas Chromatography-Mass Spectrometry
Magnetic Resonance Spectroscopy
Title Synthesis and biological activity of 3-(2, 8, 9-trioxa-aza-1-germatricyclo [3. 3. 3. 0]undecane-1-yl)-hydroxycinnamic acids
URI https://www.ncbi.nlm.nih.gov/pubmed/17897072
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