FOXO3A acts as immune response modulator in human virus-negative inflammatory cardiomyopathy

• Published in: Heart (British Cardiac Society) Vol. 109; no. 11; pp. 846 - 856
• Main Authors: Makrutzki-Zlotek, Kamila, Escher, Felicitas, Karadeniz, Zehra, Aleshcheva, Ganna, Pietsch, Heiko, Küchler, Konstanze, Schultheiss, Heinz-Peter, Heidecker, Bettina, Poller, Wolfgang, Landmesser, Ulf, Scheibenbogen, Carmen, Thevathasan, Tharusan, Skurk, Carsten
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Cardiovascular Society 01.06.2023; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Angina pectoris; Apoptosis; Autoimmune diseases; cardiomyopathies; Cardiomyopathy; Cardiomyopathy, Dilated - diagnosis; Cardiomyopathy, Dilated - genetics; Cardiovascular disease; Cell cycle; Gene expression; genetic association studies; Genomes; heart failure; Heart Failure and Cardiomyopathies; Humans; Immune response; Immunity; Inflammation; Kinases; Lymphocytes; Medical prognosis; myocarditis; Myocarditis - genetics; Oxidative stress; Patients; Stroke Volume; Ventricular Function, Left; heart failure; genetic association studies; inflammation; cardiomyopathies; myocarditis

ObjectiveInflammatory cardiomyopathy is characterised by inflammatory infiltrates leading to cardiac injury, left ventricular (LV) dilatation and reduced LV ejection fraction (LVEF). Several viral pathogens and autoimmune phenomena may cause cardiac inflammation.The effects of the gain of function F...