Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: quasi-experimental study

• Published in: BMJ (Online) Vol. 348; no. jun18 24; p. g3596
• Main Authors: Lu, Christine Y, Zhang, Fang, Lakoma, Matthew D, Madden, Jeanne M, Rusinak, Donna, Penfold, Robert B, Simon, Gregory, Ahmedani, Brian K, Clarke, Gregory, Hunkeler, Enid M, Waitzfelder, Beth, Owen-Smith, Ashli, Raebel, Marsha A, Rossom, Rebecca, Coleman, Karen J, Copeland, Laurel A, Soumerai, Stephen B
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 18.06.2014; BMJ Publishing Group LTD; BMJ Publishing Group Ltd
• Subjects: Adolescent; Adolescents; Adult; Antidepressants; Antidepressive Agents - adverse effects; Antidepressive Agents - poisoning; Cohort Studies; Drug Labeling; Drug Prescriptions - statistics & numerical data; Female; Humans; Male; Mass Media; Media; Mental disorders; Middle Aged; Product Surveillance, Postmarketing; Self destructive behavior; Studies; Suicidal behavior; Suicide; Suicides & suicide attempts; United States; United States Food and Drug Administration; Young Adult; Young adults; United States; United States > US

Objective To investigate if the widely publicized warnings in 2003 from the US Food and Drug Administration about a possible increased risk of suicidality with antidepressant use in young people were associated with changes in antidepressant use, suicide attempts, and completed suicides among young...