Intravitreal topotecan in the management of refractory and recurrent vitreous seeds in retinoblastoma

• Published in: British journal of ophthalmology Vol. 102; no. 4; pp. 490 - 495
• Main Authors: Rao, Raksha, Honavar, Santosh G, Sharma, Vishal, Reddy, Vijay Anand P
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 01.04.2018
• Subjects: Antineoplastic Agents - administration & dosage; Cancer; Cancer therapies; Chemotherapy; Child, Preschool; Cryotherapy; Drug Administration Schedule; Drug dosages; Eye diseases; Female; Humans; Infant; Intravitreal Injections; Male; Neoplasm Seeding; Ophthalmology; Patients; Pediatrics; Retina; Retinoblastoma; Retinoblastoma - drug therapy; Retinoblastoma - pathology; Retrospective Studies; Seeds; Topoisomerase I Inhibitors - administration & dosage; Topotecan - administration & dosage; Tumors; Vitreous Body - pathology; treatment other; eye(globe); retina; neoplasia

Background/aimTo evaluate the efficacy of intravitreal topotecan for refractory or recurrent vitreous seeds in retinoblastoma.MethodsIntravitreal injection of topotecan hydrochloride (30 µg/0.15 mL) was provided every 3 weeks by the safety enhanced technique.ResultsThe study included 17 consecutive...