The relationship between serum hypoxia-inducible factor 1α and coronary artery calcification in asymptomatic type 2 diabetic patients

• Published in: Cardiovascular diabetology Vol. 13; no. 1; p. 52
• Main Authors: Li, Gang, Lu, Wei-hua, Ai, Rong, Yang, Jian-hong, Chen, Fang, Tang, Zhong-zhi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.02.2014; BioMed Central
• Subjects: Asymptomatic Diseases; Biomarkers - blood; Coronary Vessels - diagnostic imaging; Coronary Vessels - metabolism; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - diagnostic imaging; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - blood; Male; Middle Aged; Original Investigation; Radiography; Vascular Calcification - blood; Vascular Calcification - diagnosis; Vascular Calcification - diagnostic imaging

Hypoxia-inducible factor 1 (HIF-1), a master regulator of oxygen homeostasis, is a heterodimer consisting of HIF-1α and HIF-1β subunits, and is implicated in calcification of cartilage and vasculature. The goal of this study was to determine the relationship between serum HIF-1α with coronary artery...