Impaired glucagon suppression and reduced insulin sensitivity in subjects with prediabetes undergoing atorvastatin therapy

• Published in: European journal of endocrinology Vol. 181; no. 6; pp. 579 - 590
• Main Authors: Urbano, Francesca, Di Pino, Antonino, Scicali, Roberto, Filippello, Agnese, Di Mauro, Stefania, Scamporrino, Alessandra, Marchisello, Simona, Rabuazzo, Agata Maria, Purrello, Francesco, Piro, Salvatore
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.12.2019; Oxford University Press
• Subjects: Adult; Aged; AKT protein; Atorvastatin; Atorvastatin - therapeutic use; Blood Glucose - drug effects; Blotting, Western; Cell Line; Clinical Study; Diabetes mellitus (non-insulin dependent); Female; Glucagon; Glucagon - blood; Glucagon - metabolism; Glucose; Glucose tolerance; Glucose Tolerance Test; Humans; Immunoprecipitation; Insulin; Insulin receptor substrate 1; Insulin Resistance; Male; Middle Aged; Multivariate Analysis; Pancreas; Phosphorylation; Prediabetic State - blood; Prediabetic State - drug therapy; Prediabetic State - metabolism; Regression analysis; Signal transduction; Statins
• ISSN: 0804-4643; 1479-683X; 1479-683X
• DOI: 10.1530/EJE-19-0173

Objective Statin therapy has been linked to an increased risk of type 2 diabetes in high-risk populations; however, the pathophysiology of this association remains to be clarified. We investigated glucagon suppression and its relationship with insulin resistance in prediabetic subjects undergoing at...