Causes, patterns and severity of androgen excess in 487 consecutively recruited pre- and post-pubertal children

• Published in: European journal of endocrinology Vol. 180; no. 3; pp. 213 - 221
• Main Authors: Idkowiak, Jan, Elhassan, Yasir S, Mannion, Pascoe, Smith, Karen, Webster, Rachel, Saraff, Vrinda, Barrett, Timothy G, Shaw, Nicholas J, Krone, Nils, Dias, Renuka P, Kershaw, Melanie, Kirk, Jeremy M, Högler, Wolfgang, Krone, Ruth E, O’Reilly, Michael W, Arlt, Wiebke
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.03.2019; Oxford University Press
• Subjects: Adolescent; Androgens; Androgens - blood; Androstenedione; Androstenedione - blood; Child; Child, Preschool; Children; Clinical Study; Dehydroepiandrosterone - blood; Dehydroepiandrosterone Sulfate - blood; Diagnosis; Endocrine System Diseases - blood; Endocrine System Diseases - epidemiology; Endocrine System Diseases - etiology; Endocrine System Diseases - pathology; Female; Humans; Male; Mass spectroscopy; Phenotyping; Puberty - blood; Puberty, Precocious - blood; Puberty, Precocious - epidemiology; Retrospective Studies; Risk Factors; Severity of Illness Index; Sexual Maturation - physiology; Testosterone; Testosterone - blood

Objective Androgen excess in childhood is a common presentation and may signify sinister underlying pathology. Data describing its patterns and severity are scarce, limiting the information available for clinical decision processes. Here, we examined the differential diagnostic value of serum DHEAS,...