Neuropilin-1 Binding Peptide as Fusion to Diphtheria Toxin Induces Apoptosis in Non-small Cell Lung Cancer Cell Line

• Published in: Current pharmaceutical design Vol. 30; no. 17; p. 1317
• Main Authors: Eghtedari, Sara, Behdani, Mahdi, Kazemi-Lomedasht, Fatemeh
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2024
• Subjects: A549 Cells; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Cell Proliferation - drug effects; Diphtheria Toxin - chemistry; Diphtheria Toxin - genetics; Diphtheria Toxin - pharmacology; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms - drug therapy; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Neuropilin-1 - genetics; Neuropilin-1 - metabolism; Peptides - chemistry; Peptides - pharmacology; diphtheria toxin; NRP-1; apoptosis; peptide; angiogenesis; target therapy

Targeted cancer therapy can be considered as a new strategy to overcome the side effects of current cancer treatments. Neuropilin-1 (NRP-1) is a transmembrane glycoprotein that is expressed in endothelial cells and tumor vessels to stimulate angiogenesis progression. Targeted diphtheria toxin (DT)-...