Network Pharmacology, Molecular Docking Analysis and Molecular Dynamics Simulation of Scutellaria baicalensis in the Treatment of Liver Fibrosis

• Published in: Current pharmaceutical design Vol. 30; no. 17; p. 1326
• Main Authors: Wang, Junrui, Wu, Zhuoqing, Chen, Xiaolei, Sun, Ying, Ma, Shuyao, Weng, Jingdan, Zhang, Yuxin, Dong, Keke, Shao, Jiangjuan, Zheng, Shizhong
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2024
• Subjects: Animals; Humans; Liver Cirrhosis - drug therapy; Liver Cirrhosis - metabolism; Liver Cirrhosis - pathology; Medicine, Chinese Traditional; Molecular Docking Simulation; Molecular Dynamics Simulation; Network Pharmacology; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Scutellaria baicalensis - chemistry; liver fibrosis; Oroxylin A; molecular docking; Scutellaria baicalensis; network pharmacology; molecular dynamics simulation

Traditional Chinese medicine (SB), one of the clinical firstline heat-clearing drugs, has obvious symptomatic advantages for hepatic fibrosis with dampness-heat stasis as its syndrome. We aim to predict and validate the potential mechanism of active ingredients against liver fibrosis more scientific...