Decreased CD8+ T cell response to Epstein-Barr virus infected B cells in multiple sclerosis is not due to decreased HLA class I expression on B cells or monocytes

• Published in: BMC neurology Vol. 11; no. 1; p. 95
• Main Authors: Pender, Michael P, Csurhes, Peter A, Pfluger, Casey M M, Burrows, Scott R
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.08.2011; BioMed Central; BMC
• Subjects: Adult; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell Separation; Epstein-Barr Virus Infections - complications; Epstein-Barr Virus Infections - immunology; Epstein-Barr Virus Infections - metabolism; Female; Flow Cytometry; Herpesvirus 4, Human - immunology; Histocompatibility Antigens Class I - biosynthesis; Histocompatibility Antigens Class I - immunology; Histocompatibility Antigens Class II - biosynthesis; Histocompatibility Antigens Class II - immunology; Humans; Male; Middle Aged; Monocytes - immunology; Monocytes - metabolism; Multiple Sclerosis - immunology; Multiple Sclerosis - metabolism; Multiple Sclerosis - virology

Patients with multiple sclerosis (MS) have a decreased frequency of CD8+ T cells reactive to their own Epstein-Barr virus (EBV) infected B cells. We have proposed that this might predispose to the development of MS by allowing EBV-infected autoreactive B cells to accumulate in the central nervous sy...