Intercalators as Anticancer Drugs

• Published in: Current pharmaceutical design Vol. 7; no. 17; pp. 1745 - 1780
• Main Authors: Brana, M. F., Cacho, M., Gradillas, A., de Pascual-Teresa, B., Ramos, A.
• Format: Journal Article
• Language: English
• Published: United Arab Emirates Bentham Science Publishers Ltd 01.11.2001
• Subjects: Animals; Antibiotics, Antineoplastic - chemistry; Antibiotics, Antineoplastic - metabolism; Antibiotics, Antineoplastic - therapeutic use; Antineoplastic Agents - chemistry; Antineoplastic Agents - metabolism; Antineoplastic Agents - therapeutic use; Humans; Intercalating Agents - chemistry; Intercalating Agents - metabolism; Intercalating Agents - therapeutic use
• ISSN: 1381-6128; 1873-4286
• DOI: 10.2174/1381612013397113

Intercalators are the most important group of compounds that interact reversibly with the DNA double helix. Some of them are valuable drugs currently used for the treatment of ovarian and breast cancers and acute leukemias, while many others are in different phases of clinical trials. Intercalating...