Dynamic treatment regimes (DTRs) to study treatment sequencing in oncology: a scoping review protocol

• Published in: BMJ open Vol. 13; no. 5; p. e067192
• Main Authors: Esteves, Susana, Alves, João Miguel, Rodrigues, Pedro Pereira, Gomes da Silva, Maria
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 30.05.2023; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Protocol
• Subjects: Cancer; Chronic illnesses; Clinical medicine; Clinical trials; Disease; Humans; Medical Oncology; Methods; ONCOLOGY; Patients; Research Design; Research Methods; Review Literature as Topic; STATISTICS & RESEARCH METHODS; Systematic Review; THERAPEUTICS; THERAPEUTICS; ONCOLOGY; STATISTICS & RESEARCH METHODS; Systematic Review

IntroductionThe rapid evolution of the therapeutic landscape in oncology poses challenges to optimal treatment sequencing. Evidence for clinical decision-making is often limited to studies focused on treatment evaluation at a single decision point, with limited capability of identifying delayed effe...