LH down-regulates gonadotropin-releasing hormone (GnRH) receptor, but not GnRH, mRNA levels in the rat testis

• Published in: Journal of endocrinology Vol. 162; no. 3; pp. 409 - 415
• Main Authors: Botte, MC, Lerrant, Y, Lozach, A, Berault, A, Counis, R, Kottler, ML
• Format: Journal Article
• Language: English
• Published: Colchester BioScientifica 01.09.1999; Portland Press
• Subjects: Analysis of Variance; Animals; Biological and medical sciences; Chorionic Gonadotropin - pharmacology; Fundamental and applied biological sciences. Psychology; Gonadotropin-Releasing Hormone - agonists; Gonadotropin-Releasing Hormone - antagonists & inhibitors; Gonadotropin-Releasing Hormone - genetics; Hormone metabolism and regulation; Immunoblotting; Luteinizing Hormone - pharmacology; Male; Mammalian male genital system; Oligopeptides - pharmacology; Rats; Rats, Wistar; Receptors, LHRH - genetics; Receptors, LHRH - metabolism; RNA, Messenger - analysis; RNA, Messenger - metabolism; Testis - drug effects; Testis - metabolism; Testosterone - pharmacology; Triptorelin Pamoate - pharmacology; Vertebrates: reproduction; Rat; Rodentia; Gonadotropin RH; Gonadotropin; Gene expression; Testicle; Male genital system; Hypothalamic hormone; Vertebrata; Mammalia; Adenohypophyseal hormone; Hormonal regulation; Luteinizing hormone; Steroidogenesis; Hormone releasing factor; Hormonal receptor

The demonstration of an inhibitory effect of gonadotropin-releasing hormone (GnRH) agonists upon steroidogenesis in hypophysectomized rats and the presence of mRNA coding for GnRH and GnRH receptors (GnRH-R) in rat gonads suggests that GnRH can act locally in the gonads. To assess this hypothesis, w...