IGF-I and IGF-I-binding proteins in rats with adjuvant-induced arthritis given recombinant human growth hormone

• Published in: Journal of endocrinology Vol. 165; no. 3; pp. 537 - 544
• Main Authors: Ibanez De Caceres, I, Villanua, MA, Soto, L, Martin, AI, Lopez-Calderon, A
• Format: Journal Article
• Language: English
• Published: Colchester BioScientifica 01.06.2000; Portland Press
• Subjects: Animals; Arthritis, Experimental - blood; Arthritis, Experimental - physiopathology; Biological and medical sciences; Blotting, Western; Dose-Response Relationship, Drug; Eating - drug effects; Fundamental and applied biological sciences. Psychology; Human Growth Hormone - pharmacology; Humans; Inflammation; Insulin-Like Growth Factor Binding Proteins - blood; Insulin-Like Growth Factor Binding Proteins - drug effects; Insulin-Like Growth Factor I - drug effects; Insulin-Like Growth Factor I - metabolism; Liver - metabolism; Male; Molecular and cellular biology; Rats; Rats, Wistar; Weight Gain - drug effects; Rat; Body weight; Rodentia; Somatotropin hormone; Arthritis; Inflammation; Insulin like growth factor binding protein; Vertebrata; Chronic; Insulin like growth factor; Experimental disease; Mammalia; Adenohypophyseal hormone; Animal; Mechanism of action

Adjuvant-induced arthritis in rats is associated with growth failure, hypermetabolism and accelerated protein breakdown. We have previously reported that adjuvant-induced arthritis in rats results in a decrease in body weight gain, pituitary GH mRNA, circulating GH and IGF-I together with an increas...