Long-Circulating Liposomal Delivery System Targeting at PDGFR-β Enhances the Therapeutic Effect of IFN-α on Hepatic Fibrosis

• Published in: Current pharmaceutical design Vol. 23; no. 20; p. 3034
• Main Authors: Li, Qinghua, Yu, Qi, Ju, Jing, You, Tiangeng, Yan, Zhiqiang, Nan, Xiangli, Zhong, Jie, Zhou, Jing E
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2017
• Subjects: PDGFβR; Interferon-α; drug delivery; hepatic fibrosis; long-circulating liposomes; target

In this study, we developed a drug of IFN-α combined with pPB-SSLs, which specifically target at platelet-derived growth factor receptor-β (PDGFR-β). The aim of this study is to improve the limitations of IFN-α including insufficient drug concentration for the target cells and side-effects causing s...