Asymmetric dimethylarginine: a key player in the pathophysiology of endothelial dysfunction, vascular inflammation and atherosclerosis in rheumatoid arthritis?

• Published in: Current pharmaceutical design
• Main Authors: Mangoni, Arduino A, Tommasi, Sara, Sotgia, Salvatore, Zinellu, Angelo, Paliogiannis, Panagiotis, Piga, Matteo, Cauli, Alberto, Pintus, Gianfranco, Carru, Ciriaco, Erre, Gian Luca
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2021
• Subjects: arterial stiffness; atherosclerosis; endothelial function; inflammation; cardiovascular risk; rheumatoid arthritis; asymmetric dimethylarginine

Patients with rheumatoid arthritis (RA), a chronic and disabling autoimmune condition that is characterized by articular and extra-articular manifestations and a pro-inflammatory and pro-oxidant state, suffer from premature atherosclerosis and excessive cardiovascular disease burden. A key step in t...