X-Ray Characterization of Pharmaceutical and Cosmetic Lipidic Nanoparticles for Cutaneous Application

• Published in: Current pharmaceutical design Vol. 25; no. 21; p. 2364
• Main Authors: Carducci, Federica, Casadei, Bruna Renata, Mariani, Paolo, Barbosa, Leandro Ramos Souza
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2019
• Subjects: Administration, Cutaneous; Drug Delivery Systems; Lipids - chemistry; Nanomedicine; Nanoparticles; Pharmaceutical Preparations - administration & dosage; X-Ray Diffraction; drug delivery systems; X-ray scattering; liquid crystalline phases; structural characterization; cubosomes; topical administration; nanoformulations; Lipid nanoparticles
• ISSN: 1873-4286
• DOI: 10.2174/1381612825666190709210211

Starting from the second half of the 1900s, the advent of nanotechnology in medicine has provoked a profound revolution in this area; at present, nanomedicine delivered a remarkably large set of research and clinically useful tools as diagnostic devices, contrast agents, analytical tools, physical therapy applications, and drugdelivery vehicles. Concerning nanoformulations for drug delivery, they are constituted by nanoparticles with dimensions lower than 1 μm, usually characterized by improved pharmacokinetics, taking advantage of specific targeting, and reduced side effects. The contributors to the present chapter are reviewing a range of papers related to the structural characterization of nanoformulations by X-ray diffraction techniques. The whole of the considered papers underlines the essential role that biophysical techniques have acquired as an essential prerequisite to understanding stability, bioavailability, and lipid, biopolymer, and drug organization in nanoformulations.